@yeja, how horrible to feel that you are in a dark hole with no way out and no hope. If you need to talk to someone, please contact the 988 Suicide & Crisis Lifeline.
– Call or text 988
– Chat with a counsellor at https://988lifeline.org/chat/

They are there 24/7.

I'm glad that you posted here in the forum. We're here and we're listening. If venlafaxine is not working for you any more, have you had a chance to talk with your prescribing doctor about what you can do next? Do you also see a therapist regularly?

To @yeja
I feel just like you but I caused my own suffering. I was successfully on Effexor 150 mg for about 40 years and in Jan. of 2024 I stupidly went off of it without proper tapering (I didn’t even know what tapering was). Stopped it at 75 mgs. The withdrawal symptoms didn’t start for about 8 months so I thought I was in the clear. How wrong I was. I became anorexic and was told by doctors I was malnourished. I am eating but I still look like a wrinkled mess. I have permanent heart palpitations, difficulty walking and talking, burning skin, horrible tinnitus, hair loss, and more. My memory is shot. I can’t leave the house. I have medications that won’t be filled by my endocrinologist unless I see him in person.How could I have been so stupid! My husband has been wonderful but he is getting upset with me pleading with him for help. There is no way he can help me. Why didn’t I leave well enough alone. I have never called the suicide hotline as I am concerned they will call the police.