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After a recent visit my Oncologist 'thought' I could add Abiraterone to my Eligard injections and upcoming radiation treatments. I have Gleason 9, Cribriform and PI but NO evidence of metastasis including lymph nodes. With the radiation and Eligard side effects I don't really want to add another drug. Abiraterone seems to have some nasty side effects posted too. Through testing I am clearly castrate sensitive right now. Any thoughts?
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I can't tell if stew80, the original poster, has heart issues or not. My husband has and had no heart issues, and abiraterone/Zytiga keep his metastatic castrate resistant prostate cancer suppressed for three years, with no serious side effects. I mention this for the people reading this thread who don't have heart issues and may be considering abiraterone, or whose doctors have recommended it to them.
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4 ReactionsThis is helpful, as we will have a decision soon about which ARPI to follow 6 rounds of docetaxel + carboplatin unusual protocol. COE suggested ‘quad’ tx of ADT and that double chemo Plus Daralutamide all at once. Our local MO compromised with starting with ADT and the double chemo, followed by the ARPI when chemo is done. Both Abiraterone and Nubeqa have been suggested. I think our MOmis leaning to Abiraterone, so been reading and finding various views on which ARPI first, but no clinical studies on this quad tx and ways to sequence it. Any studies appreciated, although I have a spreadsheet full. On another forum someone said they are doing this quad protocol at MD Anderson, but I can’t find any trials or info. Anyway, thanks for this sequence thinking.
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1 ReactionHow much Cribriform and in how many pins? I had 10% in one out of 12 pins.
The question with cribriform Is not how much there is it’s how large it is. If it’s over .25 mm it’s a real problem. If under that, Not such a big deal.
In this video, Dr. Epstein discusses the risk of cribriform and active surveillance, It’s at least a half an hour and if I remember correctly.
In my case, hot flashes, brain fog and fatigue accompany the combination of abiraterone and Lupron. I had an ECG and Holter monitor a couple months ago and all turned out fine.
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1 ReactionAs a side note I see Joe Biden has joined the PC world. Gleason 9, Grade 5, met to the bone.
Someone recently said to me - "Prostate Cancer is a tax a man pays for living a long life." I know younger men have it too, but this quote resonated for me as an 80ish year old guy.
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1 ReactionYeah, sometimes we pay the tax a bit prematurely. And unfortunately, the number of men diagnosed with de-novo metastatic PCa in their 50s (and sometimes even 40s) is rising.