Abiraterone alone for HT ADT therapy for PC

The purpose of Lupron Is to reduce your testosterone. The purpose of Zytiga Is to reduce your testosterone even more. If you’re just on Zytiga your testosterone will be very low and almost all of the side effects you get from Lupron will be there, because of Zytiga. I had terrible hot flashes with Lupron My oncologist had me take depo-provera which almost completely eliminated the hot flashes until I started on Zytiga.. Hot flashes came right back, even though I was still on depo-provera.

I know a few people that have taken Zytiga alone. I also know a few people who have gone on Enzalutamide or Darolutamide alone. I did that 6 months ago. I was on Lupron and Orgovyx For eight years, I dropped it because my Testosterone is not expected to come back after all this time.

You could pick an alternate option. The patch trial showed that taking Estrogen was just as effective as ADT, but had many fewer side effects. You might switch over to Estrodiol and stop the Zytiga. That would be equivalent to just Lupron alone which may be enough for you right now.

Look up the patch trial and present the information to your doctor to try to convince them to allow you to change your drugs.

I am in a similar state and am totally up to speed through reading/research on my S***Y situation. Quit the Lupron after 2 attempts due to horrible side effects. Dr. prescribed Abiraterone with the Lupron as PSA was creeping up. Kept up with the Abiraterone only, 4 250 mgs daily = 1000 1 hour before or 2+ hours after a meal. Latest research pointed to only 1 250mg pill daily with meal was equal I have been trying this way and SE's seem a bit less but still feel s***y. Sit down with Dr. 5/16 said this was equal to 4x250 mg WTF! why did Dr. not mention this tack on dosage? Probable $ 4 250's cost more than 1 250, Right! Just confirms my suspicion that there is much info kept from PC patients to "Build the check" as common in the restaurant business. PSA still holding at < 0.03 without the Lupron.

Lacco

If you take one pill instead of four, you have to eat the right food before taking it or it doesn’t get into your system properly. If you do take the right food having one Zytiga Is equal to having four of them on an empty stomach. As a result, your symptoms will not change.

Theoretically, you could take Zytiga alone since it really drops your testosterone more than ADT and that’s the reason you’re taking ADT in the first place.

what is Zytiga? same as Lupron. ADT does cover many different drugs,No? ADT is just a term for the type of therapy covering many drugs to turn us into a leaking, weak, stumbling, eunuch with little to none quality of life.
SW

ADT is a drug that stops most testosterone production.

There are a few
Lupron, Eligard, Orgovyx, Fermagon, Prostap, Camcevi, Lucrin, Zoladex, Trelstar, Pamorelin, or Decapeptyl

ARSI’S (Androgen receptor signaling inhibitor) Are drugs like Zytiga (abiraterone), apalutamide, Enzalutamide or Darolutamide

So with an ARSI drug such as Abiraterone you still have testosterone in your system but a receptor signaling inhibitator is now present. So PC receptor cells can't recieve testosterone? Correct?
Ischia

Well, that is true with lutamide drugs.

Abiraterone acetate is a CYP17A1 enzyme inhibitor that blocks testosterone production at its source, complementing receptor signaling inhibitors by reducing available androgens. It reduces testosterone to undetectable levels.

I seem to be having very good results with less SEs by taking only 1 250 mg pillof Abiraterone daily instead of standard of 4x250 mg. Dr. stated that with food the absorption rate is equal> With a meal is important not like on an empty stomach like 4x250mg, The food in this 1 meal is important. What to avoid,what is best for this meal?
Thanks,
Lacco

Question- do you still take prednisone with it

I was diagnosed with prostate cancer that had metastasized to a lymph node. Grade group 5 Gleason score was 9 to 10. I went through 38 rounds of radiation. They also put me on that damn Lupron and Zytiga with a steroid. I had great results with the Zytiga in one month my PSA results went from a 33 to a 0.4. I understand the use of the Lupron however, the side effects are bad. I now have arthritic symptoms in both hands. This is due to the Lupron usage. According to my hematologist oncologist, I’m in remission. I’ll take that. I get blood work done every 90 days. Check my PSA so far it’s non detect. I’ll take that.