Orgovyx side effects and handling them

Where is the best place to get info to educate myself and how well does Orgovyx contain this evil disease.

You bet.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9997646/
Resistance Exercise Training Increases Muscle Mass and Strength in Prostate Cancer Patients on Androgen Deprivation Therapy

I have been a avid worker outer for my whole adult life . I've been on Orgovyx now for 6 weeks and yes, my workouts are compromised , but I am adamant about keeping up my workouts. I'm only going to be on Orgovyx for 6 months. Supposedly , the benefit of Orgovyx is that the body recovers more quickly.

I also have Gleason 9, and I go to the Moffit Cancer Center. The radiation oncologist suggested 6 mo. Orgovyx, and that plan was reinforced by an AI tool called "Aptera AI". I have completed HDbrachy and started SBTR. I have many SE from ADT but the worst is insomnia and daytime fatigue. I believe that exercise is the best therapy. My oncologist has forbidden pickleball and bike riding, which were my go to activities, so now I walk and swim on alternate days. It all falls under the "new normal".

You are in the same boat as me, more or less.
With a median follow-up of 51 months, the 5-year PSA relapse-free survival for men with low-risk PC was 92% with the addition of ADT vs 84% without ADT (P = 0.09). The issue of RT–HT in low-risk PC patients was also indirectly addressed by a retrospective analysis conducted by Ciezki et al.28 The study included 1,668 patients with low- and intermediate-risk PC treated at The Cleveland Clinic Foundation with EBRT, RP, or prostate brachytherapy with or without androgen deprivation during 1996–2001. The 5-year biochemical recurrence-free survival (BRFS) rate was 90% vs 93% for EBRT alone or with ADT in low-risk patients.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3004567/#:~:text=Specifically%2C%20the%20overall%20survival%20(OS,CI%5D%3A%200.83%E2%80%931.39).
Those are pretty good odds , I'd say.

I used to have terrible night sweats I used to wake up and have the sheet totally soaked under me.

I have an embrlabs.com wave product (wave 2). I’ve used it for Over three years now. It’s like a refrigerator that looks like a watch and sits on the inside of your wrist. You could set up one of the buttons for their night mode . Hit the button twice and It Produces cold waves at measured times during the night and prevents hot flashes and night sweats. They used to bug me, before I got this device . When you start to feel a hot flash coming on, you hit another one of the buttons twice and it sends cold chills through your arms and it reduces the intensity, shortens the life and can stop the hot flashes if hit quickly enough.
https://embrlabs.com/

It’s Artera AI
Hopefully the test is really accurate. The NCCN guidelines call for 18 months to two years of ADT For a Gleason nine.

You should consider working with a genito urinary oncologist, The ones that specialize in prostate cancer. You are a Gleason nine which is very aggressive, it would make sense to have an GU oncologist working with you not just a radiation oncologist.

Both Orgovyx (and Firmagon) have quicker recoveries from low testosterone than the other injectables (Lupron, Eligard, Prostap, Camcevi, Lucrin, Zoladex, Trelstar, Pamorelin, or Decapeptyl) due to their different mechanisms of action. With those other injectables, expect 50% more time of side-effects than the injection was planned for; with Orgovyx (and Firmagon), side-effects often subside in a matter of weeks.

Gary, wishing you all the best from this treatment regimen. I just finished my only RT series of 44 treatments and have been prescribed Orgovyx for 24 months by my oncology team. I'm almost at six months and the side effects continue to be severe. I hope to convince the team to let me alter the plan to a shorter time. My PSA was 6 last fall, Gleason 7, N1M0 from PET. PSA immediately after RT was .11.

I'm at six months on Orgovyx and I've had every side effect listed on the Orgovyx website other than constipation. Fatigue, ED, and hot flashes are I suppose the most troublesome. I exercise daily with added resistance training to reduce muscle mass loss, try to stay busy, am moving toward plant-based diet and anything else I can think of or is recommended for lessening side effects or combating the cancer.

I have experienced all the "common" and "other" side effects except constipation, and I have been on Orgovyx five months. With this med and 44 radiation treatments during February-April, my PSA has dropped from 6 to .11. I have more tests this week and anticipate the PSA will continue to drop. The system here won't let me post the link, but if you'll go to Orgovyx dot com and click the "About" tab, the last item is "side effects."