I'm thankful to find this forum. I just completed a 2 week treatment with Fluorouracil cream. I was applying to precancerous lesion on my nose. I wasn't told much by my dermatologist except to use twice daily on my entire nose area and see her in 3 months. Thank you very much. I did not expect the reaction I got from the medication. My nose is swollen, bright red, sore, and the skin is very tight. I have various stages of blisters and scabs. I called a local pharmacist as well as the dermatology office to get further clarification such as: Can I use sunscreen during treatment? Will this redness diminish? Will my skin return to normal? It is distressing to me. I've resorted to putting a bandaid over my entire nose and wearing a hat whenever outside. I feel very fatigued and don't know if this is partially to blame. I've had MOH's surgery for a basal CA above my left eyebrow and have had other lesions burned off. This is my first experience with the cream. I'm thankful for this forum to hear your experiences. I find it very comforting thank you! I also just learned about IG-SRT and will consider that if I need future "surgery".