@sierranevadagal395, I was diagnosed with the EGFR Exon 19 mutation, Stage 2b, in 2018. In 2020, my cancer metastasized to my brain, and I had brain surgery, radiation, and started taking Tagrisso, 80mg, daily in December 2020. I'm still taking it daily.

I initially was taking 2 Immodium a day to control the diarrhea. After a couple/few months, I dropped to one a day and eventually stopped altogether. Now I take Metamucil every morning to stay regular!

The next most commonly reported side effect is a skin rash, but I've only experienced that once in the last four+ years. My dermatologist prescribed a cream that eliminated the rash within days.

The most persistent side effect I still experience is nail splitting. I take 20 mcg daily which keeps that under control. Since Biotin is also good for hair and skin, one side effect is that I have to shave and trim my nails a lot more often! My oncologist assures me Biotin doesn't interfere with any medications I'm taking, but you should check with yours before taking anything regularly.

Oh, and early on, I had to take Tagrisso away from food: at least 2 hours before and after eating, or I my stomach would object. Over time, that side effect has also gone away.

As a guy, one warning with Tagrisso is to not get anyone pregnant for 4 months after stopping, so I'm guessing that's about how long it takes the average body to adapt. But every body is different.

Hang in there. The side effects do wear off with time.