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Help needed comparing CTX & P1NP results

Osteoporosis & Bone Health | Last Active: 13 hours ago | Replies (8)

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@gently

loriesco,
you might find this https://www.youtube.com/watch?v=eqY7Bm9HiD0&list=PLRwK07HRBX0AacaOM-hn_Ut12jpdDYSUj&index=5 interesting. At26,30 in Bilezikian's presentation there is a chart reflecting the percentage rise from baseline for CTX and P1NP. We don't have your baseline before Reclast so we can't compare %ages. Ideally you'd have taken a P1NP one month in from starting Tymlos. At twelve months your P1NP would have lowered from the first month high. So we can't do comparisons (confidently). One year of Reclast would have lowered both CTX and P1NP from whatever your original base was.
I find it interesting that CTX has risen as much as it has within the year after Reclast.
I suspect that the doubling of the P1NP at twelve month is partially a reflection of the delayed PTH response after bisphosphonate. But that doubling has to be seen as good.
Thanks for posting your numbers. I'll be curious to see other responses to your post.

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Replies to "loriesco, you might find this https://www.youtube.com/watch?v=eqY7Bm9HiD0&list=PLRwK07HRBX0AacaOM-hn_Ut12jpdDYSUj&index=5 interesting. At26,30 in Bilezikian's presentation there is a chart reflecting..."

What if anything is too low a score for CTX? Endo ordered (after my request; have been on Fosamax for about 1 year, next step is Reclast per endo) both that and NTX blood tests. My CTX is 52; NTX 8.2, no discussion of P1NP. Dr. Google isn't helping much which I try to find information on CTX...NTX appears to be fine. Would love insight; only been on the annoying journey for a year!