Evista/Raloxifene

I haven't used raloxifene although I read quite a bit about this med as I was thinking about using it after Forteo.

The benefits of raloxifene are many: ease of dosing, effective antiresorptive action and breast cancer risk reduction. Its antiresorptive effect is readily reversible upon discontinuation of dosing.

The antiresorptive effect of raloxifene is considered to be modest. If someone has a high bone turnover at baseline, raloxifne may not be strong enough.

The main drawback for this drug is its clotting risk. As we age, baseline risk of clotting goes up so a thorough evaluation is essential. A hematology and/or cadiology consultation may be a good idea.

I’ve been using Raloxifene for almost a year now. No side effects except occasional mild hot flashes. It is not an aggressive therapy, but as a starting treatment point for me it made sense. Had a clear cardiac calcium scan done before starting it though, due to the clotting risk. I do not know yet if it’s working - have one more year to wait until I can do a follow-up bone density scan.

@active1 I actually need something to lock in gains from Evenity. Researched Reclast and other similar drugs and side effects are very bad.

I sometimes have high blood pressure. I wrote to my cardiologist to get his perspective on its safety for me.

Took it when it first came out. Had terrible leg cramps for over a year, even after stopping it.

When I researched this drug, blood clots were mentioned as a side effect.

True, but likely an issue only for those already at risk for them. I’m not, and I’m in good health otherwise, so I decided to take the chance.

I just started Fosamax for osteoporosis. I can't afford evenity so trying Fosamax which Medicare advantage covers. I am worried about the side effects of Fosamax, esp jaw decay. I'm on my 4 th dose and do have muscle and bone pain and headaches. I researched Evista and it seemed to have less side effects, but has possible blood clots and hot flashes. Glad to hear you're doing good on Evista with little side effects. I am going to ask my pcp about Evista. Best to you.

Here’s my take on Evista ..because I did check this out. It depends on where your osteoporosis is … for example, if you have a high dexa score in your vertebrae, this drug is good. But if you have high scores elsewhere, such as hips, this drug is not effective in preventing fractures. Also this drug comes with risks. “This medicine may increase your risk of a blood clot in your leg, your lung, or your eye. You should not take Evista if you have ever had this type of blood clot.”

Yes, the flashes are very mild tho! I’m super active, and had a clear cardiac calcium scan before starting it, so the risk of clot is very low for me. It also protects against breast cancer, so that was a plus for me (mother succumbed to it).