I want to echo what Janelle said above. I would add that with a diagnosis like AD its best to get the best care at the beginning. Mayo will be your best choice for the latest and best care and will set in place a standard of care for your wife. Even if you have to do your followup at your local doctor, you will have a course of treatment set out by the best experts in the world. And you will have the confidence that you are both doing the best you can do for her. When I battled my cancers I had that confidence in my care and treatment and it was a great comfort to me. A second opinion is always worth it.