Yes... fairly normal. But can vary patient to patient. Cumulative effects can come into play, but may not come into play as much if doing the regimen of 4 FLOT, esophagectomy, 4 FLOT. But almost always, the adjuvant 4 FLOT are much harder for patients since they're trying to recover from surgery. Many on our Zoom calls doing this if you want to check in.

Gary

My husband felt like he had a flu for the first cycle; overall very bad, with no real relief until the clinic gave him some fluids twice, as well as injections to help his body produce more white blood cells. He experienced cold sensitivity for a short time. The second time around, the sensitivity stuck around but he doesn’t feel as bad overall, just extremely fatigued. He needed to get the injections again; all of his blood counts got very low. His hair is falling out and is almost all gone, which has been hard for him. Up until that he didn’t look like he was fighting cancer. He also developed some sores all over his upper body and weird discoloration but the sores seem to be healing. He was fighting some sores trying to develop in his mouth during cycle 1 but they didn’t get bad and went away. He’s had a lot of chemo brain happening. We’re nervous going into cycle 3.