Hi @jrbris23 I think you’d get some valuable insight with a discussion started by @4health4bonnie at the beginning of her CAR-T cell therapy journey. Her transplant for MM was March 26th and this was her comment yesterday…Mother’s Day!

“Yesterday my neutrophils and platelets were normal! It is very exciting, because I can be less isolated. I went into a store today with a mask on! I also saw my daughter on mothers day. I am feeling very grateful. Doctors are happy with my post tests. I’m cheering those car t cell on, and hoping I will get to total remission (for years!)”
https://connect.mayoclinic.org/comment/1301990/
Her entire discussion from Stem cell collection to recovery is in this conversation:
Starting pre-tests for CAR-T infusion for multiple myeloma
https://connect.mayoclinic.org/discussion/car-t-infusion-
for-multiple-myeloma/

I understand the hesitancy with the period of isolation. Your wife has already had an ASCT. But the window is relatively short. Once the neutorphil count returns the strick isolation morphs over to mindful living…with precautions, of course. Moreso until she updates her vaccinations again. And at this point, she most likely hasn’t had MMR vaccinations yet so special attention needs to be taken if there’s a risk of contracting measles. It’s a highly contagious infection.

Those of us with a blood cancer will always have some level of a compromised immune system. I had a Allogenic bone marrow transplant 6 years ago. ‘Fully mature’ and in a durable remission. But I was told by my transplant team that my new ‘borrowed’ immune system still never be as robust as my factory installed model. ☺️ So, as a precaution I still mask up in certain situations where I feel exposure risk is high. Your wife will be expected to do the same throughout her lifetime. It’s a small price to pay for potentially being free from her MM.

What is the timetable on your wife’s transplant?