Yes, when I was on the big 3 I got lots of headaches. I suffer from migraines but like you did not get too many. There were times when I had migraine headaches for 2 or 3 days in a row. Nothing helped. I was not on Arikayce. A lot of the antibiotics list headaches as a side effect. They can be very exhausting. I was always hydrated but think it might have been due to stress too as this treatment is hard going. I started to use a heated wheatie pillow which you can put in the microwave it gave some relief. Hope you find some relief soon.