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Is neuropathy a Tymlos side effect?
Osteoporosis & Bone Health | Last Active: Mar 22 9:07am | Replies (15)Comment receiving replies
Since having this my dr has had me stop the drug. My blood calcium levels were normal...actually got lower on the drug. My neurologist is concerned I may have developed an auto-immune reaction, a mild form of guilain barre syndrome. This could be the case as I've read after a year or two your body can develop antibodies to the drug and it becomes ineffective. Thus it must be provoking the immune system in some way. Can anyone confirm this? It's very depressing as this was my last try to tolerate some form of bone building drug. It seems I am hyper reactive to many types of pharmaceuticals.
Replies to "Since having this my dr has had me stop the drug. My blood calcium levels were..."
@tkdesign hi, I’m sorry this happened to you. Do you have any updates on your experience? My mom has been on tymlos for several months and just was discharged from the hospital with suspected mild GBS. Your case sounds very similar. She had 5 days of IVIG.
@tkdesign I ended up having a suspect autoimmune reaction after trying it for little over a month. I was down to 2 clicks, started getting rapid increase in blood pressure on injection with dizziness on top of weeks of muscle/joint pain. That was scary so had me stop it.
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tkdesign,
Of the patients receiving Abaloparatide for 18 months, 49% developed anti-Abaloparatide antibodies, 68% of which developed neutralizing antibodies to Abaloparatide. Of these patients tested for cross-reactivity, 2.3% and 0% developed cross-reactivity to PTHrP and parathyroid hormone (PTH), respectively. Of the patients that developed cross-reactivity to PTHrP, 43% developed neutralizing antibodies to PTHrP.
https://patents.google.com/patent/US11255842B2/en
It's interesting that you would develop antibodies and cross-reactivity in such a short period of time. Additionally, guilain barre syndrome is usually not evidenced as whole leg tingling.
I'm impressed that your neurologist is aware of the possible connection.
Are you having antibody testing?
Have you tried Forteo?