@amdabrock1, I'm sorry to hear these details. Those driver mutations I listed are found primarily in nonsmokers. Chemo and immunotherapy is the current recommendation for non-small cell in smokers.

Ask your oncologist about palliative care the next time you see him. Palliative care is designed to help patients deal with the side effects of their treatments, including pain. My doctor sent me to a pain management clinic which has been able to help with my chronic pain. I pray that you can find some relief.