I have now been on Orgovyx for about 3.5 months of a 6 month regimen. I am also right now 23 days into a 28 treatment proton therapy regimen. As for the Orgovyx, I have had almost no side effects. The only thing noticeable is a lack of libido, and since I don't currently have a partner that's not a big deal. Maybe better in some ways 🙂 I've been a runner and lifter for a number of years and have continued both running (4-5 days a week) and lifting (2-3 days a week). Whether it's luck, genetics or working out the Orgovyx has been almost inconsequential. Good luck!