I had issues with probably my first 5-6 injections, but they leveled off - sometimes I feel fatigue the day after my injection, and I get occasional random leg cramps. Now my LDL dropped 80% in 6 months, my angina is gone, and my blood pressure is beginning to drop a point every few months - my cardiologist says staying on Repatha actually helps clear the arteries, so I am thrilled.