Has anyone taken Entyvio for pouchitis?

Hi, @lcevenson1951 - welcome to Mayo Clinic Connect. You've had a lot of medical issues to contend with. Sorry to hear you're experiencing pouchitis.

I'm including here some Mayo Clinic information on pouchitis, if you're interested in further background on this inflammation:

- Pouchitis https://www.mayoclinic.org/diseases-conditions/pouchitis/symptoms-causes/syc-20361991

Tagging a few members on Connect who have mentioned pouchitis and/or vedolizumab (Entyvio) @dval @sandyjr @mariajean03 @jmccartney @mollys10 @embassy @borna02 @hardingv to join this discussion and offer their experiences with vedolizumab and pouchitis:

- Has anyone taken Entyvio for pouchitis? https://connect.mayoclinic.org/discussion/has-anyone-taken-entyvio-for-pouchitis

lcevenson1951 - wondering what symptoms you've had related to your pouchitis?

The only symptom is increasing number of stools. Sometimes not even that. It is just found on endoscopy

@lisa lusier could you please untag me from this post. I’m afraid that I won’t be able to offer any useful information as I do not have a j pouch

Hi, @lisag03 - I edited the post where I tagged you so you are not even mentioned. However, you will want to mute this discussion. In the Help Center https://connect.mayoclinic.org/help-center/, you will find instructions on how to subscribe or unsubscribe from a discussion.

Basically, what you'll want to do is this:
- Go to the discussion at hand https://connect.mayoclinic.org/discussion/has-anyone-taken-entyvio-for-pouchitis/.
-Click the bell icon in the bottom right of the first message.
-Select the setting you wish (in this case, it would be "Mute this discussion").
-Click Save Setting.

I took Entyvio while I had ulcerative colitis. Unfortunately it did not work for me.

I ultimately got a total procto colectomy. I reviewed the option of a j-pouch with my CR surgeon and specifically discussed the potential for pouchitis. He said they would treat it with antibiotics, with Flagyl (metronidazole) being preferred

So I am not sure why you would be considering Entyvio unless it is more than the typical pouchitis and perhaps involves UC or Chrohn's in the pouch?

Thank you for your information. Have been on several antibiotics and biologics for pouchitis. None have worked, therefore doctor proposed entyvio.

I hope this works for you if you try it.