That is probably the best way to go, so you have advice of someone on 'your team'. This is critical.

Our problem is I have collected numerous studies that the support of Berberine during chemo to work in synergy with the specific chemo drugs we are on. I guess the problem is that all these studies and review of studies are considered "pre-clinical evidence', which apparently is not enough to launch a clinical trial (or not lucrative enough) and clinical trials are the gold for the medical community to consider it ok, ie part of standard of care. Perhaps, all the people who are using well studied repurposed drugs and botanicals, in conjunction with their standard care, are out on a limb, either keeping quiet about it or using an Integrative Oncologist.

It's a quandary - we have replaced 1 daily dose of Ibuprofen for low dose aspirin because of the studies about aspirin and prostate cancer. We want to add Berberine, but also want to work "with' our care team. As for Berberine, I am sure there must be cancer patients who come to cancer treatment already taking Metformin, and they likely continue with it during their ca treatment. From the studies, Metformin and Berberine have the same mechanism of action. I believe there are nutraceutical companies that have quality standards for their dosage, methods, and sourcing. Ok, I have carried on and probably will get booted for challenging the standard thinking, but these are just thoughts after a ton of research. We are still figuring out what other than aspirin and green tea and diet changes we want to implement. I mean, its stageIV - we want to attack from as many safe angles as possible.