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Cribriform cells: Does their presence change treatment approach?
Prostate Cancer | Last Active: May 10 4:31pm | Replies (42)Comment receiving replies
Your husband has a very aggressive form of cancer. Unless he stays on ADT or something similar, he is not going to live a long life.
Yes ADT Can cause a lot of fatigue, especially if you don’t exercise regularly. The problem is, without it the cancer will continue to grow, and it will not be pleasant.
You could talk to your doctor about monotherapy, Something like Darolutamide or apalutamide may work to reduce the cancer growth, But unless his testosterone is also managed, those drugs cannot work fully, and his PSA will probably continue to rise, just not as fast.
My father died of prostate cancer. When I was young, he had his teeth ground down and crowned without Novacaine and came to dinner every night, He had an incredible pain tolerance. He died of prostate cancer. In the last few weeks you couldn’t even talk to him because he was on so much painkillers he was not able to communicate.
Yes, ADT has it drawback, I was on it for eight years. I should know. If you can’t handle the fatigue, then you should speak to a palliative care doctor. They will work with him to resolve the problems he’s having with ADT.. Yes, he will lose some of his sex drive if he goes on ADT, But he could live for another decade. What is more important? If they put them on ADT plus abiraterone then the fatigue can be pretty bad, Adding more prednisone can make a big difference, Going to 10 mg of prednisone has helped people I know relieve some of the fatigue problems. ADT with Darolutamide would have fewer side effects. If he is on abiraterone And has heart issues it is not the right drug. I had to quit taking abiraterone Because of the effects on my heart, Darolutamide does not have similar problems.
I’ve heard from multiple people that have had prostate cancer tumors in their lungs. Going on ADT plus an ARSI can reduce those tumors, Had somebody reported they completely disappeared.
It sounds like you need to find yourself a different medical team. Is your oncologist, a medical oncologist or a Genito urinary oncologist? The GU oncologists specialize in prostate cancer and can help you a lot more. Are you working with a center of excellence? Going to a place like that may give you more options.
Replies to "Your husband has a very aggressive form of cancer. Unless he stays on ADT or something..."
Hi and thanks for your reply. He does appreciate that his life span will be reduced if he chooses not to stay on ADT, but having witnessed his sister's tragic and extremely painful death with cancer and her husbands lengthy period when terminal with prostate cancer it does also make you appreciate quality versus quantity of life. He will go back on ADT but needs a break after this last period. It wasn’t just fatigue he suffered with but also extreme pain everywhere. He has high blood pressure (stable for many years on medication) and is now being investigated for angina too since becoming breathless on hormones. It has disappeared again now it’s out of his system. With regards his sex drive, yes obviously we appreciate it’s nothing compared to living longer providing you have some quality of life too, and there’s no pressure there at all.
His oncologists are in a centre of excellence and connected to a good team (now we have moved health boards thankfully). We have no issue with them and they are always available to answer any questions, and when he decides to try hormones again we can mention the options you’ve kindly given me.
They will be monitoring closely the lung nodules, they are all under 10 mm currently but will be checked at each scan now.
Thanks again
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I have been unable to locate my metastatic cancer after RP and 8 weeks of radiation in the prostate bed and related areas. Lupron worked after 6 months treatment but PSA has now risen to 2.9 with doubling at about a 5 month rate. I am Gleason 9 Cribform, and just tried an Axumin scan after my last PSMA pet was again negative. Still no sign of where the cancer is. In short, despite the aggracivity of my disease, we have never been able to see where it has metastasized. I am seeing my oncologist next week. Is my only option ADT? I can probably live with that, but all I am doing is kicking the can. I have never had any symptoms of prostate cancer and workout regularly. Should I expect to see this cancer on a pet scan if I risk my life further by allowing my PSA to rise to four or five? This is the dilemma my face. Any thoughts would be helpful.