I only do one azithromycin but two of the others. Like others have mentioned as if you can do one of the meds week one, add in the second week two then the third week three. Probiotics should be started right away. I did initially cut the erythromycin in half to make it easier to swallow and take the Rifubutin with a spoonful of applesauce but now just swallow with water. My Dr has me space these out but I know others take them all at the same time. I do usually take with food as it seems to help but find I really have to time meals and snacks around my medication schedule.