I took the omadacycline for abscessus for at least a year and a half. I took it at 10 pm, so it would be 4 hours after supper, and plenty of time before breakfast. I didn’t have any trouble with insomnia, but it did give me nausea and vomiting. Once I started taking Zofran 30 minutes before the Omadacycline I rarely had any breakthrough nausea.