Thanks Phil. I asked my surgeon about the number of cores with Gleason 4 cells. He said that all four came from the same target lesion so probably just a sampling thing not an indication of spread throughout the prostate because all the random cores were negative. They said, he still could not guarantee that there were not other cancer cells outside the target lesion. This the reason for lower long term success rates with focal therapies. He used to be at NYU and said that focal cryotherapy was popular with wealthy men who wanted to minimize erection and incontinence side effects. The research on it's long term effectiveness is lacking.