I was also given a script for a PPI which I decided I wasn't going to take. The side effects of that drug were too scary for me. I think the Famotidine is working, so I will just stick with it. Have you had any side effects from Nexium??
Not sure how to answer. . The microscopic colitis I was finally diagnosed with after 7 months of diarrhea has four or five known medication triggers - and PPIs such as Nexium is one of them. NSAIDs and SSRI antidepressants are also triggers. I went off ibuprofen and Nexium and after the treatment for it I haven’t had any more trouble.
That said, they do state PPIs are not intended or recommended for long term use.
I've been on Omeprazole for over 10 years. I have specifically asked my GI doc in the last two-year appointments, about the long term impact or side effects from taking this drug for so long. His standard response is do you want to deal with Esophageal cancer or keep taking Omeprazole. I was on the PMR forum when one of the members mention he was also on Omeprazole and that he had found a study that tied Proton pump inhibitors (PPIs), including medications ending in "-azole" such as omeprazole, lansoprazole, pantoprazole, rabeprazole, and esomeprazole, have been associated with neurological adverse events, including peripheral neuropathy. That got my attention, so after a search on ChatGpt I found that indeed long term user have experienced adverse health effects using these drugs.
Here's what it said:
"A large-scale analysis of over 10 million FDA adverse event reports revealed that patients using PPIs had a significantly higher incidence of neurological adverse events compared to those using H2 receptor antagonists. Specifically, the odds ratio for peripheral neuropathy and related conditions was 8.68 (95% CI: 3.86–19.49; p < 0.0001) in the PPI group. This suggests a strong association between PPI use and various forms of neuropathy, including peripheral sensory neuropathy, neuralgia, and polyneuropathy."
"1. PPIs and Kidney Disease
Multiple studies now link long-term PPI use to both acute kidney injury and chronic kidney disease progression.
They may cause subtle inflammation in the kidneys over time (interstitial nephritis) even without obvious symptoms.
With stage 3 CKD, keeping your kidneys protected is huge.
2. PPIs and Neuropathy
As we discussed, PPIs are associated with vitamin B12 deficiency and magnesium deficiency, both of which can lead to polyneuropathy and worsen restless leg syndrome."
I have been diagnosed with Polyneuropathy, Carpel Tunnel, Kidney Disease, Vitamin B-12 deficiency, Magnesium deficiency and restless leg syndrome. I believe these are all caused from taking Omeprazole. Likewise, I have stopped taking it and will ask to be put on an H2 blocker, probably famotidine. I may have also had the microscopic colitis mentioned by pb50, as I suffered from explosive diarrhea for years.
Furthermore, I don't think the GI docs are familiar with these studies, otherwise I would like to think they would not be prescribing them. As we all know, we have to be our own best advocate, that's why we are on this forum. I appreciate so much everyone contribution.
The more research I do, the more I find how important our stomach bacteria is and that it may be the key to so many health issues. PPI may be destroying the good bacterial and creating additional inflammation in our bodies, possibly creating other health issues.
Connect
Connect
Like
Helpful
Hug
Not sure how to answer. . The microscopic colitis I was finally diagnosed with after 7 months of diarrhea has four or five known medication triggers - and PPIs such as Nexium is one of them. NSAIDs and SSRI antidepressants are also triggers. I went off ibuprofen and Nexium and after the treatment for it I haven’t had any more trouble.
That said, they do state PPIs are not intended or recommended for long term use.
-
Like -
Helpful -
Hug
1 ReactionI've been on Omeprazole for over 10 years. I have specifically asked my GI doc in the last two-year appointments, about the long term impact or side effects from taking this drug for so long. His standard response is do you want to deal with Esophageal cancer or keep taking Omeprazole. I was on the PMR forum when one of the members mention he was also on Omeprazole and that he had found a study that tied Proton pump inhibitors (PPIs), including medications ending in "-azole" such as omeprazole, lansoprazole, pantoprazole, rabeprazole, and esomeprazole, have been associated with neurological adverse events, including peripheral neuropathy. That got my attention, so after a search on ChatGpt I found that indeed long term user have experienced adverse health effects using these drugs.
Here's what it said:
"A large-scale analysis of over 10 million FDA adverse event reports revealed that patients using PPIs had a significantly higher incidence of neurological adverse events compared to those using H2 receptor antagonists. Specifically, the odds ratio for peripheral neuropathy and related conditions was 8.68 (95% CI: 3.86–19.49; p < 0.0001) in the PPI group. This suggests a strong association between PPI use and various forms of neuropathy, including peripheral sensory neuropathy, neuralgia, and polyneuropathy."
"1. PPIs and Kidney Disease
Multiple studies now link long-term PPI use to both acute kidney injury and chronic kidney disease progression.
They may cause subtle inflammation in the kidneys over time (interstitial nephritis) even without obvious symptoms.
With stage 3 CKD, keeping your kidneys protected is huge.
2. PPIs and Neuropathy
As we discussed, PPIs are associated with vitamin B12 deficiency and magnesium deficiency, both of which can lead to polyneuropathy and worsen restless leg syndrome."
I have been diagnosed with Polyneuropathy, Carpel Tunnel, Kidney Disease, Vitamin B-12 deficiency, Magnesium deficiency and restless leg syndrome. I believe these are all caused from taking Omeprazole. Likewise, I have stopped taking it and will ask to be put on an H2 blocker, probably famotidine. I may have also had the microscopic colitis mentioned by pb50, as I suffered from explosive diarrhea for years.
Furthermore, I don't think the GI docs are familiar with these studies, otherwise I would like to think they would not be prescribing them. As we all know, we have to be our own best advocate, that's why we are on this forum. I appreciate so much everyone contribution.
The more research I do, the more I find how important our stomach bacteria is and that it may be the key to so many health issues. PPI may be destroying the good bacterial and creating additional inflammation in our bodies, possibly creating other health issues.
-
Like -
Helpful -
Hug
1 Reaction