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Stopping ADT

Prostate Cancer | Last Active: 10 hours ago | Replies (41)

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@rdplatt2

Just joining the group here folks. Recently found T2 prostate cancer, Gleason of 3+4. PET scan shows it might be contained, however a bright spot showed up on my Thyroid and my lung. So, getting both looked into. Hoping if cancerous they can be addressed separately maybe? Have started the ADT Hormone pill Casadex and added Lupron six month shot. External beam Radiation being discussed for best timeframe. All the latest literature I read says this one, two type treatment of Hormone and Radiation has had very good longevity outcomes. Wondering if anyone cares to comment or concur? Has anyone seen a connection between Prostate adenocancer and lung or Thyroid cancer? Tks!

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Replies to "Just joining the group here folks. Recently found T2 prostate cancer, Gleason of 3+4. PET scan..."

Sorry for your diagnosis. My spinal metastasis was at T3, so we're in similar situations.

If there are only a few spots (oligometastatic), then they can often be radiated individually; Pluvicto and/or chemotherapy are more commonly indicated for many spots (polymetastatic). Note that while PSMA PET is the most-sensitive scan available, it also has a reputation for throwing up false positives, so those extra little spots may or may not be significant

For metastatic prostate cancer like ours, the STAMPEDE study demonstrated the benefit of also radiating the prostate itself within a year of diagnosis, and the TITAN trial showed a *very* strong benefit to starting Apalutamide at the same time as ADT (instead of holding it in reserve until the cancer becomes castrate-resistant).

Both of these were new ideas in 2021 when I was diagnosed (the common practice then was just to treat stage-4 palliatively), but I was lucky to be at a major Canadian cancer centre where they were up on the latest research. I hope this knowledge is more widely disseminated now, but it's still worth getting to a major cancer center/centre of excellence to make sure you're getting the benefit of the latest research, because things are changing fast.