While I'm in the camp that most non-vitamin or non-mineral minerals are likely scams, it can be difficult to determine their efficacy. For example, I do take a supplement called Regen for my peripheral neuropathy. My doctor, understandably a skeptic, reviewed the ingredients and said they were those that current medical thought suggests they could effect the condition. I do not have pain, the reduction of which would be a good measure if a supplement is working. Another complication for me is determining whether real or perceived improvement is due to the supplement or something else. With these caveats, I take Regen not so much for whether is reduces my numbness, which it appears to do, but rather to HOPEFULLY impede the condition's progress. Again, hard to measure. But you are the placebo.