Hello @janspons,

I'm joining @lisalucier in welcoming you to Connect. I am sorry to hear of your problem with nighttime fecal incontinence. While I've never had Jpouch, I have had several surgeries of the upper digestive tract which has resulted in digestive tract problems. I also have diverticulitis and I'm familiar with one of the medications you listed, Flagyl. It sounds as if you have been taking this for a while. Is that correct? Do you notice the nighttime incontinence occurring during the 2-week period when you take the Flagyl?

Flagyl has always been a problem for me and has resulted in chronic diarrhea and loose stools. One time when I was in the doctor's office for diverticulitis, the doctor wanted to prescribe Flagyl. I told him about the problem I had with it and he listed Flagyl as medication allergy. Therefore, I don't use it anymore.

You might check with your doctor to see what else you could try besides the Flagyl just to see if that med might be the culprit. Sometimes we need to be our own advocate (and detective) to find an answer to our problems.

I look forward to hearing from you again as you deal with this problem. Will you continue to post about your progress in dealing with this?