I just went from 5 to 4 mg and I’m feeling more pain and stiffness every day. My oncologist told me to check with my rheumatologist, he said 4 to 5 mg is what the Adrenal gland should produce every day. After taking Prednisone long term and at higher doses that that, the Adrenal may not be functioning yet and the body is deficient, which is a serious condition.