I have had long COVID for 3 years. PEM is the worst and it is a big symptom I have experienced. I wake up feeling poisoned and that is inflammation and PEM. I have taken Vyvanse (ADHD) medication for many years and it does help. I do not know how it helps, biologically, but when I wake up, I drink a full glass of water, mixed with Emergen-C, take my Vyvanse, Cymbalta (lowest dose 30 mg.) and Gabapentin. Within an hour or so of taking my medications and hydrating, I am able to do some things. The issue is that this is everyday. I know that if I do too much, I will pay for it the next day. I have to live in the day and do what I can and try and not think too much about tomorrow. That being said, it is always in the back of my mind. You would definitely want to make sure you have no heart issues if you are taking Vyvanse. I know that people also take Wellbutrin for ADHD, however I have no experience with it. I got so depressed and hopeless, that my psychiatrist suggested the Cymbalta. It is an SNRI (serotonin norepinephrine reuptake inhibitor). It has helped. Hang in there!