Your comment are very interesting. Since starting Eliquis I have developed significant joint pain with the worst being hands/wrists and neck plus feeling ‘off’ in the mornings in particular. As the day goes on I get better but still have pain. The marker for inflammation also has gone way up along with my WBC. Haven’t yet spoken with PCP and cardiologist about it but will be soon. I dint feel like working out and I know I could not lift weights of any weight so getting weaker.