@cathy5161 @santosha I would strongly caution anyone considering creatine supplementation for epilepsy. If possible, I’d recommend discussing it with a specialist — ideally a Mayo Clinic neurologist. While creatine deficiency syndromes (CDS) are only tangentially linked to epilepsy, that connection alone is enough to make me careful about introducing anything that could potentially affect seizure thresholds or brain chemistry.

Over the years, I’ve had neurologists recommend everything from GABA supplements to CBD and even Ketamine. However, my experience at Mayo was dramatically different. Within a short time, they pared everything down to only the antiseizure drugs (ASDs) they deemed essential — and eliminated everything else.

It was eye-opening. Whereas many other neurologists seemed eager to recommend pills or supplements — often creating more problems than they solved — the Mayo approach was focused, disciplined, and grounded in evidence.

I’ve realized since that, as much as I want my epilepsy to be “fixed,” chasing solutions through ancillary treatments had become a crutch. It gave me the illusion that I could somehow force improvement, rather than working with what is and striving to live better from that foundation.