I didn't have either. They give you an intense anti-nausea medication when they infuse the melphalan. Then, I took Zofran around the clock, to prevent any nausea. They told me to watch out for diarrhea which I had one or two episodes that resolved right away. They will tell you what to look out for, in case they have to test for infections.

They will have you chew ice the whole time the infusion is happening (about 30 minutes for each infusion). Keep your mouth absolutely freezing cold - the ice will numb your mouth and keep the chemo from getting to it. It totally worked for me - my mouth was slightly redder than normal and my gums felt sore for about one or two days, but that's it, no sores at all.