My husband had the same experience with Lonsurf, then had Y90 placed directly into his liver , that worked well and now he’s also on Fruzaqual. At full strength his sodium level got very low ( I thought he had a stroke) hospitalization for 5 days , still a bit confused when I bought him home the next morning it was like it never happened. So now he takes half the dose and that is shrinking the tumor but they are now also watching his protein levels in his urine ( high) doing urine/ blood tests every 2 weeks