It’s not just Orgovyx, The same is true of every ADT drug Orgovyx, Lupron, Fermagon, and Eligard.

Eventually, you will become castrate resistant And you will need a second drug an ARSI (Zytiga or a lutamide). I had my first ADT drug fail 2.5 years after I started it, when my PSA started rising, so I went on Zytiga. It’s now about four years later, And I switched to Darolutamide. I’ve been undetectable for 18 months and even stopped taking Orgovyx about six months ago and because I was on ADT for eight years. Testosterone is really not coming back. The whole purpose of ADT is to suppress testosterone.

Even though ADT stopped working, it did not completely stop working so I continued to take it even though I was castrate resistant and it did keep my Testosterone low still. That just didn’t keep my PSA down. I needed the second drug to do that..

The Titan study showed that staying on ADT plus apalutamide could enable you to stay castrate resistant longer, resulting in longer overall survival.. It’s another thing to just consider, Maybe someone else could speak about this.