Everyone has different reactions to chemotherapy, but I do know the advances made in anti-nausea meds has been significant. Personally, I was on a clinical trial of Folfox 5 and only had slight symptoms of tiredness and tingling. Otherwise, it was very tolerable and highly successful. I had an esophagectomy on November 1st and now am on Optdivo immunotherapy. Again, very minor side effects. Wishing you well.