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Wegovy (semaglutide) and Nausea

Bariatric Surgery & Weight Loss | Last Active: Sep 22 4:34pm | Replies (59)

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Profile picture for Lisa Lucier, Moderator @lisalucier

Not to worry at all, @jc76. Just wanted to be sure other members here understood what you meant.

I recall you said if you changed to tirzepatide (Zepbound) you'd have to wait a bit first. What are your thoughts right now about changing to tirzepatide (Zepbound), jc76?

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Replies to "Not to worry at all, @jc76. Just wanted to be sure other members here understood what..."

@lisalucier
I am not against trying Zepbound in the future.

I work very closely with my Mayo Jacksonville PCP who I trust very much. He recommended I wait for about 3 months after my reaction to Wegovy's 2.4 dose to consider Zepbound. I meet with him every 3 months not only for my weight but I am recovering from prostate cancer where he does a PSA test every 3 months and we go over those results.

When he explained why Zepbound may work better for me it was because it has 2 receptors versus only one for Wegovy that affect the brain appetite. I got only a slight reduction in appetite at dinner, and that was only from lunch meal digestion slow down.

On Wegovey I had not reduction of appetite for breakfast, lunch, just dinner. And that was very small. I told my PCP I would have to eat more for breakfast to get the same feeling at lunch that I get at dinner which is just adding more food.

Per my PCP he said I would have to start at the low dose of Zepbound like I did with Wegovy. I really don't know what happened to my body. I used to be able to lose weight quickly by reducing calories.

I exercise 6 days a week and on most days 2 hours. I do water aerobics 8 times a week (on 3 days do back-to-back classes. Then I swim at least one day for a mile and ride my bike at least one day for 20 miles. I don't eat any more at meals than I did 20 years ago probably less. My downfall is snacks and is not sweets. I love mixed nuts, but a quarter of a cup (which is a ridiculously small number of nuts) is 185 calories.