Just horrible.........this seems like a bad trade off. They got rid of the reflux after 20 years of suffering, and traded for horrible constipation and distension of stomach and pain. Unfortunately Mayo clinic dropped the ball!!!! Left me suffering for weeks and now I'm waiting for appointments and this is my the quality of life now. I've made food logs. Several appointments with diaticians. changed diet several times. Tried Miralx, Collace, Metamucil. It appears it doesnt matter what I eat or my physical activities. I am going a bit nuts over this.....