Docetaxel and Carboplatin

Posted by round5 @round5, Jul 12, 2023

Anyone received both of these chemotherapy drugs for prostate cancer and if so how’d it work?

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@lag

My husband had six rounds of docetaxel in 2016 after new spinal lesions started cropping up too fast to treat them only with spot radiation. He had the usual chemo side effects, which were at their worst in week one after the infusion, and which got better over the next two weeks--until it was time for the next infusion. He had no serious side effects such as the ones described by sillyoyster above, and the docetaxel reduced his PSA to undetectable for a long time. Everyone reacts differently to cancer medications, so do discuss the pros and cons of docetaxel with your oncologist, and don't dismiss it out of hand. It is very effective for many men.

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How long did it reduce his PSA? Quality of life afterwards? Thanks

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@round5

Thank you for your reply. I too never had any of the severe things mentioned above, and I also received Carboplatin. A lot of stage four prostate cancer patients have received Docetaxel But few have received Carboplatin with it, which makes it tougher and those were the people I was wanting to hear from.

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Me, too.

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@chippydoo

How long did it reduce his PSA? Quality of life afterwards? Thanks

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It was years ago, but my recollection is that it kept his cancer suppressed for quite some time. His quality of life was good once he was a few weeks out from the sixth round of infusions.

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@jajaime22

Alguien que haya recibido una combinación de Docetaxel mas Darolutamida me podría indicar que resultados se han obtenido . En mi caso voy para la sesión 5 de 6 y el PSA cuando inicie era de 10.02 y a la fecha este está en 14 , la idea era rebajarlo según indicaciones de mi Médica Oncóloga Clínica siendo clasificado con : CPRCnm y clasificado con progresión bioquímica , de ahí la formulación de Darolutamida de 300 mg con una dosis de 2 tabletas cada 12. horas

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@jajaime22, I can imagine that you are concerned that your PSA is rising after 5 of 6 chemo treatments of docetaxel plus Nubeqa (darolutamide). What has your oncologist suggested as next steps and options?

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Concretamente me dice " terminemos todo el esquema , ósea las 6 sesiones y analizamos resultados : hemograma y otros indicadores , ademas acompañado de un PET SCAN con PSMA y observamos detenidamente lo pertinente para orientar opciones a seguir

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