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Biopsy follow up meeting questions?
Prostate Cancer | Last Active: 15 hours ago | Replies (10)Comment receiving replies
Thanks for the reply. Here are the actual results from the biopsy. The first two are the cores that were positive from the pattern coring, the last one is the three cores from the lesion shown on the MRI. Meeting with Urologist to start this week.
Gleason score 4 + 3 = 7
Percentage of pattern 4: 80-90%
Grade Group: 3
Tumor involves 80-85% of overall specimen (1 of 1 core).
Gleason score 4 + 3 = 7
Percentage of pattern 4: 80%
Grade Group: 3
Tumor involves 40-50% of overall specimen (1 of 1 core).
Gleason score 4 + 3 = 7
Percentage of pattern 4: 90%
Grade Group: 3
Tumor involves 30% of overall specimen (3 of 3 cores).
Most affected core is involved by tumor over % of its
length.
Perineural invasion: Present
Cribriform glands: Present
Replies to "Thanks for the reply. Here are the actual results from the biopsy. The first two are..."
Hey 54, @jeffmarc has given you excellent info and perspective. Your age is also a consideration.
If you are relatively young, surgery is a good option since cribriform pattern is a more serious issue and this type of cancer ‘could’ recur in the future; you could then have radiation.
If you are older - say 75 and up, you have to discuss life expectancy with your doctors. General health - good/not so good- is also a factor.
High Dose Brachytherapy + SBRT/IMRT is a good alternative if you are not a candidate for surgery (advanced age, poor health). The seeds give a big initial killing boost to the cribriform area and the follow up radiation treats the gland/margins. Standard radiation protocols alone may not eradicate the cribriform cells. Best,
Phil
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Last thing in the list is one of the big issues “ Cribriform glands: Present” means that your cancer is more aggressive than 4+3. Regular SBRT radiation cannot completely remove Cribriform, you need more radiation or surgery.
Perineural invasion can be removed by radiation or surgery so it’s not an issue.
There was a high percentage of 4 in the cores. Tumor involvement was over 50%.
It would be useful to know the size of the cribriform, If it’s over .25 mm then it is more serious