Hi everyone,
I posted about the NEJM article to my social media and one of our bronchi-sisters sent this reply regarding her experience with brensocatib:

I was having multiple exacerbations a year before the trial. On antibiotics for weeks, sometimes months, at a time. The only reason I went on the trial was to be able to have regular access to the respiratory clinic (monthly visits throughout the 14 mth trial period) as, in NZ, the moment you get well you’re dropped from the clinic, then have to be re-referred by your GP when you’re next unwell. However the referral process takes so long you’re probably better again by the time your appointment arrives. I have not had a single exacerbation, nor taken antibiotics for infection in my lungs (have had covid twice and upper respiratory tract virus which in the past would’ve definitely led to lung infection), since I started the medication. In the past I had periods where I felt my job could be in jeopardy because of the amount of coughing I did at work. I no longer cough, except as part of airways clearance. I have little mucus and do not feel as though I have respiratory disease. I’ll be 70 in June, have a daily step goal of 13,000 steps (I’m a fast walker), work full time, exercise at home daily. No one would be able to guess I have respiratory disease. My disease is classed as ‘moderate’.

Someone else posted that she did not feel better while on a drug in the study. She and her doctor assumed she was on the placebo.

I hope this is helpful, Linda Esposito