@chrunt Welcome to Mayo Clinic Connect!

As @sepdvm mentioned, we are all so different. What has your wife's medical team explained to her may be causing the headaches? Does it have to do with side effects of her medical condition, or possibly medications, or treatments? Taking all of those into consideration and exploring the possibilities, while it takes effort, can really help her come to a decision how to address it. What kind of nerve block was done, and what has been your wife's diagnosis?

A pattern of severe headaches, often times leading into a migraine, has been part of my life for a long time. Is it the change in weather patterns, as the barometric pressure wildly swings? Is it from my health conditions? Are the beneficial treatments being offset by the side effects? If so, how can we adjust it all? Is it something in my diet? Let me tell you what I finally did. After research and hesitation, 3 weeks ago I got a daith ear piercing. It has been noted this often works for people suffering from headaches. For me, I figured if it doesn't work, I have only gained [another] ear piercing. The result? In the 3 weeks since, I have gone from daily headaches, to no headaches in 3 weeks! A miracle in my book! This piercing uses a spot often accessed by acupuncture practicers that interrupts the vagus nerve. The person who did my piercing said almost all their clients who do this experience permanent relief. Count me in on the benefits. Heck, even if the headaches were to return tomorrow, there were 3 weeks of no symptoms.
Ginger