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Side effects of prednisone

Polymyalgia Rheumatica (PMR) | Last Active: Jul 2, 2025 | Replies (23)

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I was told by the rheumatologist that I would have some jitteriness, a "little" weight gain (20 pounds now and counting), and possible mood swings. I asked if it would affect my Afib. She said not. It has. I've also had headache, vertigo, and a general feeling of "crummy" most days all days. I wasn't told about the diabetes possibility until I did my own research and talked to my PCP, who said "oh yeah, we should test for that." So far my A1C is normal. I know we have to advocate for ourselves and I do my own research but it seems fairly simple for the prescribing physician to give us a simple handout of prednisone side effects. It's not like they are a secret. I've also learned there are supplements, like chromium picolate, that can help with blood sugar and cravings. Of course, I do not expect allopathic docs to know about those.

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Replies to "I was told by the rheumatologist that I would have some jitteriness, a "little" weight gain..."

I'm surprised that no sheet of side effects comes with my prescription bottles of prednisolone. Rather than from the doctor, side effects lists are usually given at the pharmacy. Like you, I've looked most of it up myself and many people wouldn't bother.

The way we individually react to prednisone is different with a lot of variables like diet and activity levels, pre-existing conditions and other medications we're already taking, so the list of possible side effects would be very long.

Weight gain is not inevitable. I eat strictly low carb/sugar, high protein and no processed food or gluten, a dietary change I'd made to lose weight shortly before PMR struck. I haven't gained a pound in (almost) two years on prednisone, and blood pressure and blood tests are all good. But without dietary changes to mitigate the metabolism changes caused by prednisone - which messes with the digestion of sugars and fats and sends strong hunger signals even when our body doesn't need food - I'd have gained weight, no doubt. I expect dietary advice isn't given because either the digestion changes prednisone causes aren't fully understood by doctors or most people aren't willing to change eating habits.