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Replies to "It seems we are far enough down the line with the advances in PCa, that testing..."
Prostate Cancer | Last Active: 20 hours ago | Replies (17)
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It seems we are far enough down the line with the advances in PCa, that testing for androgen sensitivity (prior to trial) should/could be an important step. I am a wee bit flummoxed that we have had 2 liquid biopsies, 2 mets tissue biopsies and there is no 'knowing' about the cancer's reliance on Testosterone - its an assumption that it is, versus a fact. Is is true for all who are ADT virgins? just assume the cancer depends on T? Being rhetorical...
Replies to "It seems we are far enough down the line with the advances in PCa, that testing..."
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I think that might be overstating the problem a bit. There's no test for individual cancer cells loose in the body, period — they can't detect them until they start forming tumors — so there would be no way with current tech to detect if some of those cells are evolving castrate resistance.
But they can measure by impact. Prostate cancer cells express PSA when they're multiplying, so if ADT brings your PSA down, then at least a lot of your cancer is castrate sensitive; if it doesn't, then at least a significant portion of it is evolving castrate resistance.