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Upcoming SBRT: Any advice to help me prepare?

Prostate Cancer | Last Active: 4 days ago | Replies (19)

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@northoftheborder

Did he possibly say ADT and the second generation ARSIs (ending in "-lutamide", like Apalutamide or Enzalutamide)? Those definitely work better together, as many studies have demonstrated.

They're all hormone therapy, but they work differently: ADT like Lupron or Orgovyx blocks testosterone production, while ARSI blocks testosterone reception by the cancer cells, so you're attacking it at both ends.

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Replies to "Did he possibly say ADT and the second generation ARSIs (ending in "-lutamide", like Apalutamide or..."

North, If someone becomes castrate resistant, the ARSI would no long work, right?
Is the next step a PARP inhibitor - Or is that just for BRCA mutations?
Phil