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Replies to "Dr. Scholz also commented that 1st and 2nd generation ADTs work better than either alone. That..."
Prostate Cancer | Last Active: 21 hours ago | Replies (14)
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Dr. Scholz also commented that 1st and 2nd generation ADTs work better than either alone. That was to related to mets not tissue sensitization to primary whole gland radiotherapy.
Replies to "Dr. Scholz also commented that 1st and 2nd generation ADTs work better than either alone. That..."
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Did he possibly say ADT and the second generation ARSIs (ending in "-lutamide", like Apalutamide or Enzalutamide)? Those definitely work better together, as many studies have demonstrated.
They're all hormone therapy, but they work differently: ADT like Lupron or Orgovyx blocks testosterone production, while ARSI blocks testosterone reception by the cancer cells, so you're attacking it at both ends.