At one stage I went up to 100 mg daily (for 5 days only) then down to 50 mg for a longer period to treat the rising inflammation of CRP (well over 100). It looked like I was starting to develop GCA symptoms and it was decided that hitting it hard was the best option. There was no formal diagnosis of GCA and no biopsy - I think largely because the high CRP told the story. It was a successful approach and possibly quite common. But tapering is hard and slow and I'm not eligible for Actemra as I don't have a GCA diagnosis. Coming up to nearly 2 years with PMR and after 18 months of methotrexate it see,s to have stopped doing anything at all, but make me feel worse for a day or so after taking it.