Exercise may be the single most potent medical intervention ever known

Posted by Sirref @sirref, 5 days ago

Text and Summary taken from NotebookLM from the podcast.

This YouTube video transcript features a conversation between Eric Topol and Euan Ashley about the benefits of exercise.
Exercise may be the single most potent medical intervention ever known.
Two PDF files are attached
Briefing Document: Euan Ashley on the Potency of Exercise
Summary of YouTube video transcript

Quotes: From Podcast

"exercise may be the single most potent medical intervention ever known" - Euan Ashley's summary of the research.
"we really don't have a a more potent medical intervention especially for prevention of disease I mean it's just s such a a powerful thing that we have uh and yet we don't really understand how how it works" - Euan Ashley on the motivation for MoTrPAC.
"it's very very clear from looking at all these tissues that when you exercise regularly you are just a different person or in this case a different rat like literally every tissue is changed dramatically" - Euan Ashley on the systemic impact of exercise.
"sex basically came out every single time... sometimes it appeared like we're almost dealing like with two different species they were so different" - Euan Ashley on the profound sex-specific differences in exercise response.
"there may be ways we could mimic some elements of exercise but there's no pill this is a multi-system multi- tissue you know multi-dimensional response to exercise" - Euan Ashley on the limitations of a pharmacological "exercise pill."
"one minute of exercise bought you five minutes of extra life" - Euan Ashley referencing a large epidemiological study.

Shared files

Exercise_Medicine_Topol (Exercise_Medicine_Topol.pdf)

Exercise_Briefing_Document (Exercise_Briefing_Document.pdf)

Interested in more discussions like this? Go to the Aging Well Support Group.

imallears | @imallears | 5 days ago

@sirref

Excellent! Thank you for this. Potency….the power to affect change….is such an important choice of one word. Everyone should read this excerpt.

FL Mary

seniormed | @seniormed | 5 days ago

Exercise is medicine.

rabNok | @rabnok | 3 days ago

Hello, I am new to these forums although I have “lurked” around a bit, reading many content threads of interest since joining. This title caught my attention as I know exercise/movement is the single most important aspect of living with 2 spine fusions. ‘Motion is Life’s Lotion’ is a phrase my neurosurgeon used bluntly, telling me “not adhering to an exercise regimen will contribute heavily to your failure to achieve maximum functional recovery.” I’m not the smartest guy in the room but at 65, have learned (1), seek out & listen to certified experts and (2), experience is what you get when you didn’t get what you wanted SO LEARN from it. Great article & I wish you all success in managing & living with your respective ailments.

Ginger, Volunteer Mentor | @gingerw | 3 days ago

In reply to @rabnok "Hello, I am new to these forums although I have “lurked” around a bit, reading many..." + (show)

@rabnok Welcome to Mayo Clinic Connect! Your neurosurgeon sounds like a wise person! That phrase is short but powerful, and the comment they made is definitely something to take to heart, don't you agree?

How long ago were your spine fusions? And, how are you doing now? You may want to wander through the Spine Health group https://connect.mayoclinic.org/group/spine-health/ and see if you can share your experiences there, also!
Ginger

ruby2zdy | @ruby2zdy | 3 days ago

Have any of you gotten concussions? I fell 2 yrs ago & it's affected my short-term memory, attention span, and peripheral vision. I read via the NIH that they developed a medicine (I am NOT selling this, I don't know anybody who makes it -- I'm just sharing info) that's been shown to repair the brains of rats who have Alzheimer's (rats with Alzheimer's???) by doing something to the tau tangles that prevent neurotransmission in that disease and this stuff is available OTC.

Its organic chem name is 1,7,9-tetramethyluric Acid (OTC name Dynamine™ or Methylliberine). I haven't tried it, just learned about it today. You can get it at Amazon. I'm desperate to stop my memory loss from getting worse, so I'm gonna try it .I'd like to hear back from people who try it & have good results with their memory, etc.

rabNok | @rabnok | 3 days ago

In reply to @gingerw "@rabnok Welcome to Mayo Clinic Connect! Your neurosurgeon sounds like a wise person! That phrase is..." + (show)

Hi Ginger, thank you for insights & yes, agree wholeheartedly, staying active/moving is one thing we can control when faced with physical & emotional obstacles. I had L4-5 fused successfully with inter-body cages in 1998. No real issues until 2017, a backwards fall coming off a ladder, 4+ years trying EVERYthing to avoid the knife, finally arriving at the point of no options other than fusing T11-L5 with rods & screws. I’m upright, moving & breathing every day 😊 staying positive is also a must; so many folks going through things much, much worse than my daily trials. I do keep an eye on Spine Health as well & thanks again for the warm greetings! rb