It’s pretty clear you are castrate resistant, and the drugs are not working for you. At this point, I would think they’d want to do chemo or Pluvicto (lu 177).

Since they have now approved Pluvicto For people who have not had chemo, This may be good for you to try first. Speak to your doctor about that, Find out why one procedure would be better for you than the other.

You may want to have somatic genetic testing to see if any Genetic changes have occurred. They can affect how well Pluvicto works. If you have no genetic issues in your hereditary test, you could still have somatic issues come up in your cancer cells.

Pluvicto genetic issues
RB1, PTen, TP53 are Pluvicto resistant
ATM & BRCA work better with Pluvicto

Since you’ve already had Enzalutamide it is unlikely Darolutamide will work any better . Ask your doctor about this.