@surftohealth88 Thank you for your reply and your kindness which comes through your words. It’s a major center team recommending the aggressive treatment as they suspect something unusual by the low psa and the visceral (lung) metastasis. And yes, the long ‘remission’ or years not doing more than distantly watching were a blessing as we launched our children. We are just figuring out retirement now, and not alone in a diversion from that promise. I think we have settled to go with our oncologist and do the heavy chemo as the first response. There is a lot in the literature about sequencing therapies, and while much is known about, much still represents ‘million dollar questions’. Given the ‘high volume’ because it’s the lungs, even with the slowness so far and low mutational burden, we are likely to settle with the chemo first attack followed by Abiraterone and the big center team has said while not the most ideal, they support that. My hub has felt fine, but admittedly has lost weight unexpectedly along with stamina due to postponing a hip replacement. The full quad onslaught seems like it could be really challenging. I wish most of all, they could do more testing to tell what is the makeup of theses cancer cells. I thought the liquid biopsies would give us some of that footprint, but the results have not center discussed. There are 4 mutations but not the obvious brca or atm and more obvious mutations seen with prostate cancer. Berliner testing was also negative for the obvious. So,…alas…as many navigating this journey there is the body of unknown that has more to say. We have to choose what we are unsure of and …trust…..I guess.