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Abiraterone Acetate: What were your side effects?
Prostate Cancer | Last Active: Apr 25 9:49am | Replies (16)Comment receiving replies
On Abiraterone since Jan PSA still going up to 218 Not happy Oncologist keeps meon it
Have done Xtandi, Radium 223 and 2 chemo's that caused my lungs to fill with fluid Prednisone and oxygen for 6 moths then Abirat
Is darolutamide better? No insurance issues for me
I did PSMA PET and qualify for LU 177 as C only in bones Had radiation T 4 to T 7 and hip Pain still in shoulder
Advise please
Replies to "On Abiraterone since Jan PSA still going up to 218 Not happy Oncologist keeps meon it..."
It’s pretty clear you are castrate resistant, and the drugs are not working for you. At this point, I would think they’d want to do chemo or Pluvicto (lu 177).
Since they have now approved Pluvicto For people who have not had chemo, This may be good for you to try first. Speak to your doctor about that, Find out why one procedure would be better for you than the other.
You may want to have somatic genetic testing to see if any Genetic changes have occurred. They can affect how well Pluvicto works. If you have no genetic issues in your hereditary test, you could still have somatic issues come up in your cancer cells.
Pluvicto genetic issues
RB1, PTen, TP53 are Pluvicto resistant
ATM & BRCA work better with Pluvicto
Since you’ve already had Enzalutamide it is unlikely Darolutamide will work any better . Ask your doctor about this.
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The -lutamides are approved for specific cancer situations. In my case, I'm on Apalutamide (Erleada) + ADT because the TITAN study demonstrated that combo was more effective than any other horomone therapy for treating metastatic castrate-sensitive prostate cancer (mCSPC). The SPARTAN study also demonstrated Apalutamide's effectiveness for non-metastatic castrate-resistant prostate cancer (nmCRPC).
Other -lutamides are approved for various situations, but I don't know as much about them.