← Return to Is there anyone that had estrogen positive cancer, without use of AI?

Discussion

Is there anyone that had estrogen positive cancer, without use of AI?

Breast Cancer | Last Active: 2 days ago | Replies (152)
Comment receiving replies
@jig4891

Thank you for the informative response. I am just starting an AI and have many concerns. I took it for 10 days and had to stop due to severe pain in my feet and hands. I took plenty of meds to help, but to no avail. I'm considering trying another one, based on the recommendation of my doctors. However, I am not sure I even want to continue to try due to all of the toxic ramifications. It's not an easy decision though. Your response is very helpful.

Jump to this post

Replies to "Thank you for the informative response. I am just starting an AI and have many concerns...."
peggydobbs | @peggydobbs | 3 days ago

My advice is to try all AIs (including Fulvestrant) and Tamoxifen before you give up. I did poorly on Exemestane and Letrozole and OK on Anastrozole. Please be aware that in a sense all cancer drugs are toxic. Below is something I posted on a different thread. But it might be helpful.

Alternative dosing letrozole: https://pmc.ncbi.nlm.nih.gov/articles/PMC4740217/
Alternative dosing tamoxifen: https://pmc.ncbi.nlm.nih.gov/articles/PMC11101371/
Alternative dosing exemestane: https://pubmed.ncbi.nlm.nih.gov/36951827/
Alternative dosing anastrozole: No studies that I could find.

According to my medical oncologist, the studies cited above show that lower doses of AIs or Tam lower estrogen just as well as higher doses. What these studies do **not** show is that lower doses are as effective as usual (higher) dose in reducing risk of recurrence. Of course, that doesn't mean that lower doses don't work--but there's no scientific evidence that they do.

VIEW AND REPLY